Fragile X Carrier Screening Test (AFE)Back

The incidence of fragile X syndrome in mental retardation syndrome caused by chromosomal abnormalities is second only to Down's Syndrome, with an average IQ of less than 70

 

What is fragile X syndrome?

· Fragile X Syndrome(Fragile X Syndrome / FXS)is one of the most common diseases of inherited mental retardation, which affects about 1/4000 men and 1/8000 women

· The carrying frequency of men is as high as about 1/800, and the carrying frequency of women is as high as about 1/260

·If the female carries the FMR1 gene mutation, there will be a 50% chance of passing it on to the next generation

Source: http://www.fragilex.org

Self Photos / Files - 0104_advantage33

 

Feature of AFE

· Suitable for everyone

· According to research, if the mother is a carrier of fragile X chromosome, the baby boy has a greater chance of becoming a fragile X syndrome patient

 

What is the cause of fragile X syndrome?

· The cause of FXS is caused by the FMR1 gene (CGG) sequence expansion mutation on the X chromosome

· Defects or mutations in the FMR1 gene prevent the gene from correctly making a protein called FMRP, and this protein plays an important role in the function of the nervous system, resulting in abnormal physical and cognitive behavior.

Self Photos / Files - ___6

 

Common symptoms of fragile X syndrome:

Physical characteristics

Male: High forehead, big chin and long ears

Female: Symptoms are less severe and maybe characterized by joint hyperextension

 

Cognitive behavioral characteristics

Male: Learning difficulties (IQ below 70)

Female: Mild to moderate intellectual disability

 

Is fragile X syndrome testing necessary?

· High incidence and low intelligence

· High probability of passing to men, male babies are more dangerous

· Affecting a lifetime and cannot be cured

· Asymptomatic female carriers

· As the age of pregnant women increases, the risk will increase

Source: Hong Kong Fertility Technology & Prenatal Diagnosis Centre

 

Fragile X syndrome screening process

  1. Draw 6 ml of blood
  2. Report issue within 1 working day after blood draw
  3. Obtain screening results for Fragile X Syndrome
  4. Assess the risk of the next generation of fragile X syndrome
 
 
Price: HK$ 1,600
Add to Cart
 
AFE_product_w price-01-01

The incidence of fragile X syndrome in mental retardation syndrome caused by chromosomal abnormalities is second only to Down's Syndrome, with an average IQ of less than 70

 

What is fragile X syndrome?

· Fragile X Syndrome(Fragile X Syndrome / FXS)is one of the most common diseases of inherited mental retardation, which affects about 1/4000 men and 1/8000 women

· The carrying frequency of men is as high as about 1/800, and the carrying frequency of women is as high as about 1/260

·If the female carries the FMR1 gene mutation, there will be a 50% chance of passing it on to the next generation

Source: http://www.fragilex.org

Self Photos / Files - 0104_advantage33

 

Feature of AFE

· Suitable for everyone

· According to research, if the mother is a carrier of fragile X chromosome, the baby boy has a greater chance of becoming a fragile X syndrome patient

 

What is the cause of fragile X syndrome?

· The cause of FXS is caused by the FMR1 gene (CGG) sequence expansion mutation on the X chromosome

· Defects or mutations in the FMR1 gene prevent the gene from correctly making a protein called FMRP, and this protein plays an important role in the function of the nervous system, resulting in abnormal physical and cognitive behavior.

Self Photos / Files - ___6

 

Common symptoms of fragile X syndrome:

Physical characteristics

Male: High forehead, big chin and long ears

Female: Symptoms are less severe and maybe characterized by joint hyperextension

 

Cognitive behavioral characteristics

Male: Learning difficulties (IQ below 70)

Female: Mild to moderate intellectual disability

 

Is fragile X syndrome testing necessary?

· High incidence and low intelligence

· High probability of passing to men, male babies are more dangerous

· Affecting a lifetime and cannot be cured

· Asymptomatic female carriers

· As the age of pregnant women increases, the risk will increase

Source: Hong Kong Fertility Technology & Prenatal Diagnosis Centre

 

Fragile X syndrome screening process

  1. Draw 6 ml of blood
  2. Report issue within 1 working day after blood draw
  3. Obtain screening results for Fragile X Syndrome
  4. Assess the risk of the next generation of fragile X syndrome


Fragile X Carrier Screening Test (AFE) Service Procedure Q&A

The principle of Fragile X Carrier Screening Test (AFE)

This screening genetic test is to detect whether the CGG repeat number of the FMR1 gene is abnormal by analyzing PCR amplified gene fragments.

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Service Procedure

PART 1 : Purchase a Test Service via Diagcor Lab Website

  1. Choose your test.
  2. Read the purchase information carefully.
  3. After reading purchase information, please press"Add to Cart".
  4. Sign up for a new member account. If you already have a member account, please log-in.
  5. Proceed to the shopping cart page and press "Check Out".
  6. Please fill in all the required personal information of the testee for verification later on by the
  7. Proceed to WeChat pay or PayPal online payment system. (After the transaction is done, a confirmation SMS would be sent to client's phone.)

PART 2 : Dial DiagCor Lab to Make an Appointment.

  Please dial DiagCor Lab Service hotline: +852 51805747/+86 15507562957 to make an appointment.

PART 3 : Go to the Clinic to Claim Certain Test Services

  Please go to the clinic on the scheduled appointment date for ultrasound examination and blood draw. The testee has to present ID card & the confirmation SMS to claim the test services.

PART 4 : Receive Report

  • Once the report is ready, the clinic will inform you to collect your report.
  • If you need report counselling service, please contact the clinic.
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Q&A

QWho needs fragile X syndrome testing?

  1. If the family has a history of tremor symptoms after 50 years old 
  2. If there's family history of autism
  3. If the family has a history of intellectual development problems or slow growth
  4. If the family has history of fragile X syndrome
  5. If the family has a history of ovarian failure or early menopause
  6. If you are concerned about the possibility of your children inheriting fragile X syndrome (being a mother / prospective mother)

 

** In addition to the prospective mothers who want to take the fragile X carrier test to protect the health of their next generation, it can also be suitable for all pregnant women, as part of the prenatal check.

QI have no obvious symptoms, why do I need to conduct Fragile X syndrome test?

  1. Women who have no symptoms on the surface may still be carriers of fragile X chromosomes, and have a 50% chance of inheriting the mutated gene to the next generation, making their children sick.
  2.  If a daughter is born, she has a 50% chance of becoming a fragile X chromosome carrier. If a boy is born, he has a 50% chance of being fragile X syndrome.

QUnder what circumstances can this genetic test not be done?

If the subject has undergone organ transplantation, they cannot accept this test. (Da Accor will not accept this sample for testing)

QWhat do I need to prepare for the Fragile X Syndrome Test (AFE), do I need an empty stomach?

No special preparation is required, no fasting.

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